超重及肥胖者血浆游离脂肪酸浓度与动态血压的关系

Correlative between serum FFA and ambulatory blood pressure in overweight and obesity subjects

目的:探讨超重及肥胖者血浆游离脂肪酸(FFA)水平及动态血压的关系。方法:检测57例超重及肥胖者和56例体重正常者血浆FFA、血脂、血糖、胰岛素(INS)浓度,并检查24h动态血压。结果:超重及肥胖者血浆FFA、甘油三酯(TG)、血糖、INS及24h平均血压水平均较对照组显著升高(P<0.01),且超重与肥胖者血浆FFA浓度与24h平均血压呈正相关,SBP(r=0.406,P<0.01),DBP(r=0.361,P<0.01)。结论:超重及肥胖者血浆游离脂肪酸浓度升高,可能与高血压的发病有关。

Objective：To investigate the relationship between serum free fatty acids（FFA）and ambulatory blood pressure in overweight and obesity subjects.Methods：Serum FFA,fasting blood sugar,lipid and insulin（INS）,24h ambulatory blood pressure were measured in 57 overweight,obesity subjects and 56 normal subjects matched for age and sex.Results：overweight and obesity subjects had higher serum FFA,FBS,TG,INS and blood pressure levels compared with normal subjects（P〈0.01）;there were significantly positive correlation among FFA and 24h mean systolic blood pressure（r=0.406,P〈0.01）,24h mean diastolic blood pressure（r=0.361,P〈0.01）.Conclusion：higher serum FFA may play an important role in the hypertension pathogenesis of overweight and obesity subjects.