急性冠脉综合征高同型半胱氨酸血症与血叶酸等的关系

Correlation among homocysteine level and plasma folic acid,vitamin B_(12) in patients with acute coronary syndrome

目的:测定急性冠脉综合征(ACS)患者中血浆高同型半胱氨酸(Hcy)水平,研究其与血浆叶酸、维生素B12的关系。方法:对52例ACS患者与46例对照组患者的血浆Hcy及叶酸、维生素B12水平进行比较分析。结果:ACS患者血浆Hcy含量明显高于对照组(P<0.01),而血浆叶酸和维生素B12水平明显低于对照组(P<0.01)。两组血浆Hcy含量与叶酸、维生素B12含量呈负相关(r=0.505,0.405,P<0.01)。结论:高Hcy血症通过加速动脉粥样硬化而导致急性冠脉综合征。补充叶酸、维生素B12或许对急性冠脉综合征的防治有益。

Objective：To study the correlation among homocysteine level and plasma folic acid,Vit B12 in patients with acute coronary syndrome.Methods：The level of plasma Hcy、folic acid and Vit B12 in treatment group（52 cases）and control group（46 cases）were compared.Results：The plasma Hcy level in the treatment group was obviously higher than that in the control group（P〈0.01）,and the levels of plasma folic acid and VitB12 in the treatment group were obviously lower than those of control group（P〈0.01）.The plasma Hcy concentration appears negative correlation with the level of plasma folic acid and VitB12（r=0.505,0.405,P〈0.01）.Conclusion：The higher plasma Hcy may be corelated with acute coronary syndrome.Recruitment of folic acid and VitB12 may be benefit to against the acute coronary syndrome.