支架置入患者心型脂肪酸结合蛋白与左心室舒张早期/晚期速度峰值比值的关系

The relationship between the concentration of heart type fatty acid binding protein and the ratio of left ventricular diastole peak in early stage/late stage in patients treated with stent implantation

目的了解支架置入患者术后心型脂肪酸结合蛋白(H-FABP)浓度与左室舒张早期/晚期速度峰值比值(Ve/Va)的关系。方法冠状动脉前降支支架置入患者49例按冠状动脉造影后TIMI血流分为A组(0～1级,26例)、B组(2～3级,23例)2组,测定术后24h内H-FABP动态变化;分别于支架置入术前及术后6个月采用组织速度成像法(QTVI)测定左心室Ve/Va,并计算变化值(ΔVe/Va);分析H-FABP峰值标准化比值(RPNV)与△Ve/Va的相关性。结果B组患者术后H-FABP的RPNV值明显高于A组(P<0.01);术前与术后6个月的△Ve/Va与术后H-FABP的RPNV值呈负相关(r=-0.81,P<0.05)。结论支架置入患者术后H-FABP浓度的升高与冠状动脉狭窄程度及手术操作过程有关。

Objective To investigate the relationship between the concentration of cardiac heart fatty acid bending protein （H-FABP） and diastolic function of left ventricle. Methods 49 patients were divided into two groups according to the results of the TIMI blood stream levels detected by coronary arteriongraphy： group A （0 - 1 grade, n = 26） , group B（2 - 3 grade, n = 23）. The dynamic variations of H-FABP within 24 hours after steat implantation were measured and compared. The ratio of left ventricular early diastole peak in early stage/late stage（△Ve/Va） before operation and 6 months later were detected by quatitative tissue velocity imaging（QTVI） and the variations of △Ve/Va were calculated. The correlation between RPNV of H-FABP and △Ve/Va was analyzed. Results As com- pared with those in group B, the RPNV of H-FABP was significantly higher than that in group A （ P 〈 0.01 ）. The △Ve/Va before operation and 6 months later was negatively correlated with RPNV of H-FABP （ r = -0.81, P 〈 0.05） .Condusion The increase of concentration of H-FABP in patients treated with steat implantation is related with the degree of coronary artery stenosis and operation procedure.