复方盐酸利多卡因用于颅脑手术术后镇痛的效果

Effect of Compound Lidocaine Hydrochloride on Postoperative Pain after Craniotomy

目的探讨复方盐酸利多卡因(克泽普)术前局部浸润麻醉对颅脑手术患者术后镇痛的效果。方法40例幕上占位性病变拟行开颅肿瘤切除术患者随机分为克泽普组和对照组各20例。克泽普组于切皮前行克泽普切口和皮瓣逐层浸润;对照组行0.5%普鲁卡因局部浸润,术后行芬太尼患者自控静脉镇痛。采用视觉模拟评分比较术后48h内两组患者的疼痛程度及因镇痛所致副作用发生情况。结果两组患者术后疼痛评分和副作用发生率差异无显著性意义(P>0.05)。结论克泽普局部浸润操作简便,术后镇痛效果明显,无明显副作用发生,能够安全有效地应用于颅脑手术术后镇痛。

Objective To explore the effect of preoperative local blocking with compound lidocaine hydrochloride （CLH） on postoperative pain of patients undergoing craniotomy. Methods 40 patients suffered from superatentorial occupying lesion and scheduled for craniotomy were randomly divided into the CLH group and control group with 20 cases in each group. In the CLH group, local blocking with CLH was performed just before craniotomy, while in control group local blocking with 0.5% procaine was performed preoperatively and all patients of two groups used patient-controlled intravenous analgesia （PCIA） with fentanyl postoperatively. Postoperative pain was assessed for 48 hours according to visual analogue scale （VAS）, and the comparison of analgesia-related postoperative complications of the two groups was demonstrated. Results There was no significant difference in VAS postoperatively and incidence rate of complications between two groups （P〉0.05）. Conclusion Compound lidocaine hydrochloride local infiltration may provide a safe and effective analgesia for postoperative pain in patients after craniotomy.