摘要
Platinum nanoclusters were deposited along the supercoiled DNA strands after incubation of cis-(trans-1R,2R-diaminocyclohexane)(dl-camphorato)platinum(Ⅱ) (Cdp),an analogue of the anti-tumor drug-carboplatin,with DNA and K2PtCl4 for 600 min and then through reduction of dimethylaminoborane (DMAB). The decrease of absorption of DNA at 260 nm indicates the coordination of Cdp and DNA. TEM and AFM were employed to characterize the morphologies and structures of platinum nanoclusters.
Platinum nanoclusters were deposited along the supercoiled DNA strands after incubation of cis-（trans-1R,2R-diaminocyclohexane）（dl-camphorato）platinum（Ⅱ） （Cdp）,an analogue of the anti-tumor drug-carboplatin,with DNA and K2PtCl4 for 600 min and then through reduction of dimethylaminoborane （DMAB）. The decrease of absorption of DNA at 260 nm indicates the coordination of Cdp and DNA. TEM and AFM were employed to characterize the morphologies and structures of platinum nanoclusters.
出处
《无机化学学报》
SCIE
CAS
CSCD
北大核心
2007年第8期1481-1484,共4页
Chinese Journal of Inorganic Chemistry
基金
国家自然科学基金资助项目(No.20571042)
江苏省青蓝工程项目资助。
关键词
铂纳米团簇
DNA
二甲基硼烷
platinum nanoclusters
DNA
dimethylaminoborane
