无肝素血液透析对透析效率的影响

The Relevant Consequences of Heparin Free Hemodialysis on Dialysis Efficiency

目的:评定无肝素血液透析(heparin free hemodialysis,hfHD)对实际尿素清除率的影响。方法:收集500例次用肝素、500例次无肝素的血液透析资料,计算Kt/V和透析效率,对比两者的差异。结果:标准肝素透析(hemodialysis,HD)和hfHD的理论上的Kt/V值之比、实际的Kt/V值之比及透析效率之比分别为:(1.73±0.28)/(1.64±0.34),P>0.05;(1.41±0.30)/(1.34±0.36),P>0.05;(0.80±0.13)/(0.78±0.18),P>0.05。结论:血流速率提高后的hfHD技术并不显著降低溶质的实际清除率,不需要延长单次血透治疗的时间。

Objective： To define the clinically relevant consequences of heparin-free hemodialysis （hfHD）. Methods： Two groups of hemodialysis treatments were performed, one group with 500 patients was performed with heparin, and the another group with 500 patients was performed as hfHD. Prescribed and delivered Kt/V and dialysis efficiency were calculated respectively. Results： The prescribed Kt/V was 1.73 ± 0.28 for standard hemodialysis with heparin vs. 1.64 ± 0.34 for hfHD （P 〉 0.05）. The delivered Kt/V was 1.41 ±0.30 vs. 1.34±0.36 （P〉0.05）. Efficiency was 0.80 ±0.13 vs. 0.78±0.18 （P〉0.05） .Conclusion： The properly modified hfHD technique does not compromise delivery of dialysis. Increased treatment time is not necessary.