滋养细胞肿瘤侵袭转移的分子机制研究进展
被引量:1
摘要
妊娠滋养细胞肿瘤是来源于胎盘滋养细胞的特殊疾病,其发生、发展是多种因素参与的、极其复杂的病理过程,主要是滋养细胞运动、浸润及迁移能力发生异常。癌基因、抑癌基因、蛋白水解酶、细胞因子等在妊娠滋养细胞肿瘤侵袭转移中起到不同的作用,认识这些因素对妊娠滋养细胞肿瘤侵袭转移的调节作用,可加深对妊娠滋养细胞肿瘤发生发展的认识,有望对其进行早期预测并进行有效治疗。
出处
《国外医学(妇产科学分册)》
2007年第4期262-265,共4页
Foreign Medical Sciences(Obstet Gynecol Fascicle)
参考文献20
-
1Bilban M, Ghaffari-Tabrizi N, Hintermann E, et al. Kissprptin-10, a KISS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts[J]. Cell Sci, 2004, 117(8): 1319-1328.
-
2Jeanneau JL, Maldonado-Estrada J, Tachdjia G, et al. Transcriptional expression of genes involved in cell invasion and migration by nom and tumoral trophoblat cells[J]. Clin Endocrinol Metab, 2002, 87 (11): 5336-5339.
-
3Yazaki-Sun S, Daher S, de Souza Ishigai MM, et al. Correlation of c- erbB-2 oncogene and p53 tumor suppressor gene with malignant transformation of hydafidiform mole [J ]. J Obstet Gynaecol Res, 2006, 32(3): 265-272.
-
4Hube F, Reverdiau F, Iochmann F, et al. Transcriptional silencing of the TFPI-2 gene by promoter hypermethylation in choriocarcinoma cells[J]. Biol Chem, 2003, 384(7): 1029-1034.
-
5Yamamoto E, Ito T, Abe A, et al. Ikaros is expressed in human extravillous trophoblasts and involved in their migration and invasion[J]. Mol Hum Repred, 2005, 11(11): 825-831.
-
6Staun-Ram E, Goldman S, Gabarin D, et al. Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion[J]. Reprod Biol Endocrinol, 2004, 2: 59.
-
7Okamoto T, Niu R, Yamada S, et al. Reduced expression of tissue inhibitor of metalloproteinase(TIMP-2) in gestational trophoblastic diseases[J]. Mol Hum Reprod, 2002, 8(4): 392-398.
-
8Karmakar S, Das C. Regulation of trophoblast invasion by IL-1β and TGF-β1 [J]. Reprod Immunol, 2002, 48(4): 210-219.
-
9Karmakar S, Das C. Modulation of ezrin and E-cadherin expression by IL-1 beta and TGF-betal in human trophoblasts [J]. Reprod Immunol, 2004, 64(1-2): 9-29.
-
10Anteby EY, Greenfield C, Natanson-Yaron S, et al. Vascular endothelial growth factor, epidermal growthfactor and fibroblast growth factor-4 and -10 stimulatetrophoblast plasminogen activator system and metalloproteinase-9[J]. Mol Hum Reprod, 2004, 10(4): 229- 235.
同被引文献40
-
1乔宠,程大丽,张淑兰,王春晖,林其德.KiSS-1基因和基质金属蛋白酶-9在滋养细胞浸润调控中的作用[J].中华医学杂志,2005,85(12):839-842. 被引量:16
-
2乔宠,王春晖,尚涛,林其德.胎盘组织KiSS-1及metastin表达在早发重度子痫前期发病中的作用及其与围生结局的相关研究[J].中国妇幼保健,2007,22(25):3571-3576. 被引量:7
-
3Lee J H,Miele M E,Hicks D J,et al.KISS-1a novel human malignant melanoma metastasis-suppressor gene[J].J Natl Can-cer Inst,1996,88(23):1731-1737.
-
4Kanda S,Oka Y.Evolutionary insights into the steroid sensitive kiss1and kiss2neurons in the vertebrate brain[J].Front En-docrinol,2012,3:28.
-
5West A,Vojta P J,Welch D R,et al.Chromosome localization and genomic structure of the KiSS-1metastasis suppressor gene (KiSS1)[J].Genomics,1998,54(1):145-148.
-
6Gottsch M L,Clifton D K,Steiner R A.Kisspeptin-GPR54sig-nalingin the neuroendocrine reproductive axis[J].Mol Cell En-docrinol,2006,254-255:91-96.
-
7Ohtaki T,Shintani Y,Honda S,et al.Metastasis suppressor gene KiSS-1encodes peptide ligand of a G-protein-coupled receptor[J].Nature,2001,411(6837):613-617.
-
8Masui T,Doi R,Mori T,et al.Metastin and its variant forms suppress migration of pancreatic cancer cells[J].Biochem Bioph Re Co,2004,315(1):85-92.
-
9Prentice L M,Klausen C,Kalloger S,et al.Kisspeptin and GPR54immunoreactivity in a cohort of518patients defines favourable prognosis and clear cell subtype in ovarian carcinoma[J].BMC Medicine,2007,5:33.
-
10Harms J F,Welch D R,Miele M E.KISS1metastasis suppression and emergent pathways[J].Clin Exp Metastas,2003,20(1):11-18.
二级引证文献3
-
1马晓丽,刘开东,贺建宁,柳楠.山羊多胎性状候选基因的研究进展[J].家畜生态学报,2014,35(5):7-12. 被引量:7
-
2金慧慧,刘秋月,狄冉,胡文萍,王翔宇,储明星.Kiss1基因调控哺乳动物繁殖性能的研究进展[J].家畜生态学报,2015,36(8):1-6. 被引量:8
-
3徐林,丁伟,薛峰,尹继炜,易超.KiSS-1基因在胆管细胞癌的表达及临床意义[J].现代肿瘤医学,2016,24(4):611-614. 被引量:1
-
1耿硕,冯凤芝,向阳.耐药性妊娠滋养细胞肿瘤的手术治疗[J].中华妇产科杂志,2010,45(8):629-631. 被引量:3
-
2管维,叶章群,蓝儒竹,周惜才,李家贵,周四维,李震,吴人亮,王志华,胡志全,庄乾元,余虓.肾集合管癌的诊治[J].现代泌尿生殖肿瘤杂志,2009,1(1):61-62. 被引量:2
-
3高小曼,常建民.原发性皮肤CD30^+间变性大细胞淋巴瘤1例[J].中国麻风皮肤病杂志,2010,26(11):807-808. 被引量:1
-
4更有效的前列腺癌生物标记[J].基础医学与临床,2006,26(5):470-470.
-
5尚丽新,王心.妊娠滋养细胞肿瘤的手术和放射治疗[J].中华临床医师杂志(电子版),2013,7(4):3-5. 被引量:5
-
6唐慧敏.卵巢胚胎癌1例[J].医师进修杂志,1998,21(2):82-82.
-
7刘霞,潘小玲.滋养细胞肿瘤转移浸润相关因子研究进展[J].中华妇幼临床医学杂志(电子版),2008,4(4):67-69. 被引量:3
-
8张勤建,颜建英.E-钙黏素在胎盘植入发病中的作用[J].中华围产医学杂志,2015,18(4):306-309. 被引量:1
-
9王琳,李小平,魏丽惠.梅毒伴妊娠滋养细胞疾病1例报道[J].中国计划生育和妇产科,2013,5(2):79-80.
-
10王心,尚丽新.妇科恶性肿瘤防治系列讲座(6) 妊娠滋养细胞疾病的诊治与预防[J].人民军医,2013,56(6):715-717. 被引量:2