摘要
目的:研究疏冠胶囊(Corocalm)对麻醉犬心肌血流量(MBF)和心肌耗氧量(MOC)的影响。方法:25只行气管插管犬的冠脉血流量(CBF)用电磁血流计测得并计算心肌血流量(MBF),动脉氧含量(AO2)和冠状静脉窦氧含量(VO2)通过血氧分析得出,同时其他心脏血流动力学参数,如心率(HR)、股动脉血压(BP)通过多道生理记录仪测定。结果:Corocalm(48.5mg/kg和194mg/kg)能明显增加MBF,降低冠状动脉阻力;而且能够降低AO2,同时增加VO2,最终导致MOC明显降低。结论:Corocalm能够通过调节冠脉阻力,降低心肌耗氧量,从而维持心脏血液供应和心肌耗氧量之间的平衡。
AIM： To investigate the effects of Shuguan Capsule on myocardial blood flow （MBF） and myocardial oxygen consumption （MOC） in anesthetized dogs. METHODS： Coronary blood flow （CBF） of twenty-five thoracotomized dogs was detected by electromagnetic flow meter and the MBF was calculated. While the oxygen content in the artery （AO2 ） and in the coronary venous sinus （VO2） was determined with blood oxygen analysis. Moreover, the other cardiac hemodynamic parameters, such as heart rate （HR）, femoral arterial blood pressure （BP）, were observed by physiological polygraph. RESULTS： It was found that Shuguan Capsule （48.5 mg/kg and 194 mg/kg） could significantly increase the MBF, and then decease the coronary artery resistance. Furthermore, Shuguan Capsule could also lower the AO2, but increase the VO2, which led to the decreased MOC. CONCLUSION： Shuguan Capsule exhibits the effects to keep the balance between blood supply and oxygen consumption in the heart by modulating the coronary resistance and by reducing MOC in dogs.
出处
《中成药》
CAS
CSCD
北大核心
2007年第8期1115-1119,共5页
Chinese Traditional Patent Medicine
基金
National Key Technology Programs Foundation during the 9th Five-Year Plan Period(No.96-903-01-02)
关键词
疏冠胶囊
心肌血流量
心肌耗氧量
杂种犬
Shuguan Capsule （Corocalm）
myocardial blood flow
myocardial oxygen consumption
mongreldog
