灯盏花素壳聚糖-海藻酸钠微囊的制备与释药机制考察

Studies on the Preparation Technology and Drug Release Mechanism of Breviscapine Chitosan-alginate Microcapsules

目的考察灯盏花素壳聚糖-海藻酸钠微囊的制备工艺和释药机制。方法采用复凝聚法制备了灯盏花素壳聚糖-海藻酸钠微囊。采用常用模型拟合探讨其药物释放机制。结果所得微囊的制备工艺简单,大小均匀,载药量大且药物含量均匀。结论利用复凝聚法制备灯盏花素海藻酸钙微囊方法简单,药物释放机制为骨架溶蚀作用。

Objective To investigate the preparation technology and the drug release mechanism of Breviscapine chitosan - alginate microcapsules. Methods Breviscapine chitosan - alginate microcapsules were prepared by coacervation technology. Model - fitting were used to study the release mechanism of Breviscapine from the microcapsules. Results Prepared Breviscapine chitosan -alginate microcapsules has such advantages as simple technology, uniformity in diameters and drug loading. Conclusion The preparation procedure is simple. And the release of Breviscapine can be described as matrix erosion.