不同性别精神分裂症患者P_(300)的追踪研究

A follow-up study of P_(300) in schizophrenic patients between different sex

目的通过比较精神分裂症患者不同性别P300各指标的差异,并对其进行追踪研究,探讨不同性别精神分裂症患者的病变特点。方法对病例组71例首发或停药半年以上符合DSM-Ⅳ有关精神分裂症的诊断标准的精神分裂症患者在维思通治疗前及治疗后6个月进行事件相关电位P300检查及阳性与阴性症状量表(PANSS)评定,对对照组71例健康志愿者进行事件相关电位P300检查。结果病例组急性期未用药时,男性N2P3潜伏期、P2非靶刺激潜伏期长于女性(P<0.05),正常对照组男性的N2P3波幅及P2非靶刺激波幅高于女性(P<0.05);服药半年后病例组男性与女性相比,P300各指标的差异消失。结论①男女患者大脑兴奋性和信息加工速度均受损,男性受损程度更严重。②N2P3潜伏期、P2非靶刺激潜伏期可能是状态性指标。

Objective To explore the features of schizophrenic patients between male and female by comparing the differences of P300 in normal and schizophrenic patients and follow-up study.Methods Seventy-one schizophrenic patients diagnosed by DSM-Ⅳ standard at the first occurrence or stopping drug for 6 months were selected.The event-related potential P300 and PANSS were recorded in 71 schizophrenic patients before treatment and after treatment for 6 months.Event-related potential P300 were also recorded in 71 normal controls.Results ①In schizophrenic patients,N2P3 and P2 latency of male was longer than that of female.In normal controls,N2P3 and P2 wave amplitudes of male were higher than that of female.②After treatment for 6 months,there was no different in N2P3 and P2 latency between male and female of schizophrenic patients.Conclusion ①In schizophrenic patients,the excitability and the message-elaborating speed of cerebrum are damaged both in male and female,but more severe in male.② The N2P3 and P2 latency may be a state index.