妊娠高血压疾病孕妇血清催乳素及尿酸水平的关系

Relationship between serum prolactin and uric acid in hypertensive disorders complicating pregnancy

目的研究妊娠晚期妊娠高血压疾病(HDCP)患者血清催乳素(PRL)及尿酸(UA)水平变化并揭示PRL与UA相关性,评价它们与围生儿预后的关系。方法选择妊娠晚期妊娠高血压疾病孕妇69例(轻度31例,重度38例),并设正常妊娠晚期孕妇33例为对照组,检测血清PRL及UA水平,同时观察围生儿预后。结果重度子痫前期组血清UA值较轻度子痫前期组及对照组均明显升高(P<0.05),轻度子痫前期组与对照组血清UA值有升高,但组间差异无统计学意义(P>0.05);重度子痫前期组血清PRL值较轻度子痫前期组及对照组降低,但仅重度子痫前期组与对照组组间差异有统计学意义(P<0.05);子痫前期随血清UA升高围生儿预后不良发生率增加;HDCP患者血清PRL及血清UA水平变化二者无相关性,但它们与新生儿体重有弱的相关性(PRL:r=0.30,P<0.05;UA:r=-0.29,P<0.05)。结论妊娠晚期重度子痫前期患者血清PRL表现为降低,而血清UA表现为升高,但HDCP患者血清PRL及血清UA水平变化二者无相关性。利用血清UA水平衡量HDCP病情严重程度及预测围生儿预后情况有一定的实用价值。

Objective To investigate the changes of serum prolactin（PRL）and serum uric acid（UA）in late trimester of pregnancy about hypertensive disorders complicating pregnancy（HDCP）,and to explore their correlation and evaluation to perinatal prognosis.Methods The levels of maternal serum PRL and UA were determined in 69 pregnant women with HDCP（mild preeclampsia,n=31;severe preeclampsia,n=38）and normal pregnant controls（n=33）.Perinatal prognosis was observed.Results The serum UA levels were significantly higher in severe preeclampsia[（323.52±88.37）μmol/L] than in mild preeclampsia[（270.19±72.32）μmol/L] and normal pregnant women[（239.85±62.02）μmol/L]（P〈0.05）,but there was no significant difference between control group and mild preeclampsia group（P〉0.05）.The serum PRL level in severe preeclampsia was the lowest among three groups,but there was significant difference only between control group and severe preeclampsia group（P〈0.05）.There was no significant correlation between serum prolactin level and serum uric acid level,but they were slightly related to the infant weight（PRL：r=0.30,P〈0.05;UA：r=-0.29,P〈0.05）.Conclusion Serum PRL decreases,and serum UA increases in severe preeclampsia of late trimester of pregnancy.But there is no significant correlation between serum PRL and serum UA.Serum UA has clinical value for evaluating the degree of HDCP and predicting the prognosis.