北京地区2005年12月～2006年4月下呼吸道感染住院患儿病毒病原检测分析

Analysis of Viral Pathogens in Hospitalized Children with Lower Respiratory Infection in Beijing Area from Dec.2005 to Apr.2006

目的探讨病毒病原在北京地区下呼吸道感染住院患儿中感染特点,为儿童急性下呼吸道感染的诊断和治疗提供参考。方法连续采集2005年12月～2006年4月北京儿童医院因急性下呼吸道感染住院患儿的鼻咽分泌物。采用间接免疫荧光法检测7种呼吸道病毒抗原,包括呼吸道合胞病毒(RSV)、流感病毒(IV)A、B型、副流感病毒(PIV)1、2、3型及腺病毒(ADV)。结果共935例患儿采集了鼻咽分泌物标本。男597例,女338例;年龄1d～6岁,平均7.5个月。935例标本中检出阳性516例(55.2%)。RSV是各年龄组下呼吸道感染的主要病毒病原,所占比例随年龄增加而下降;IV和PIV所占病例随年龄增加而增加,ADV只在3岁以下儿童病例中检出,所占比例为0.6%～6.2%。结论病毒病原是2005年12月～2006年4月北京地区引起儿童下呼吸道感染的主要病原,以RSV为主,其次是IV和PIV。

Objective To explore the characteristics viral pathogens in hospitalized children with lower respiratory infection,and to provide reference data for diagnosis and treatment. Methods Nasopharyngeal secretion （NPS） samples were collected from hospitalized patients with lower respiratory infection （LRI） from Dec. 2005 to Apr.2006. The NPS samples were detected for 7 respiratory virus antigens including respiratory syneytial virus （RSV） ,influenza virus A and B （IVA and IVB） ,parainfluenza virus 1,2,3 （PIV 1,2,3） and adenovirus （ADV） by indirect immunofluorescent assay. Results Nine hundred and thirty - five NPS samples were collected from children （597 boys,338 girls） with LRI. The mean age was 7.5 months （ range from 1 day to 6 years）. Viral pathogens were identified in 516 （ 55.2% ） samples. The positive rate of RSV decreased with increasing of age, whereas the positive rate of IV and PIV increased. ADV was only detected in children less than 3 years of age, accounting for 0.6% - 6.2%. Conclusions Viral pathogens are the main etiology of LRI in young children in Beijing area from Dec.2005 to Apr. 2006. RSV is the most frequent viral pathogens,followed by IV and PIV.