病毒性肺炎婴幼儿呼吸道合胞病毒免疫球蛋白M抗体检测的意义

Significance of Respiratory Syncytial Virus-Immunoglobulin M Detection for Diagnosis in Children with Viral Pneumonia

目的探讨呼吸道合胞病毒(RSV)-IgM抗体对婴幼儿病毒性肺炎的诊断价值。方法婴幼儿病毒性肺炎108例(间质性肺炎76例,毛细支气管炎32例)和健康对照组40例,采用间接免疫荧光法(IIF)检测其血清RSV-IgM抗体。结果间质性肺炎患儿血清RSV-IgM抗体阳性率48.68%(37/76例);毛细支气管炎患儿RSV-IgM抗体阳性率为25.0%(8/32例),二组有显著性差异(χ2=5.20P<0.05)。间质性肺炎、毛细支气管炎组阳性率均明显高于健康对照组(χ2=28.59,11.25Pa<0.05)。病毒性肺炎婴幼儿RSV-IgM阳性率发热病例最高,占81.97%(50/61例),其次为呼吸困难占57.14%(12/21例),最低为气促,占26.87%(18/67例)。结论RSV-IgM抗体检测是婴幼儿病毒性肺炎诊断中重要参考指标之一,其检测对提高该疾病的诊断、指导治疗和估计预后均有重要意义。

Objective To explore the diagnostic value of detecting respiratory syncytial virus（RSV） - IgM for viral pneumonia in children. Methods Seventy - six cases with interstitisl pneumonia,32 cases with bronchiolitis among 108 cases children with viral pneumonia and 40 healthy children as control group were included,BSV -IgM was detected by indirect imrnunofluorescence in 108 children with viral pneumonia and healthy control group. Results The positive rates of BSV - IgM in 76 cases with interstitisl pneumonia and 32 cases with bronchiolitis were 48.68% and 25.0% ,respectively, there was significant difference between 2 groups （ χ^2 = 5.20 P 〈 0.05 ）. And compared with control group, there were significant difference （ χ^2= 28.59,11.25 Pa 〈 0.05 ）. The positive rates of BSV - IgM in 61 cases with fever,21 cases with dyspnea and 67 cases with dyspneea were 81.97% （50/61 cases） ,57.14% （12/21 cases）and 26.87% （18/67 cases） ,respectively. Conclusion BSV - lgM is one of the important indexes in viral pneumonia in children and can prove the diagnsis and therapy of viral pneumonia in children.