选择性海马切除对难治性癫痫患者个性改变的影响

Effects of selective resection of hippocampu on personal characteristic variation of patients with intractable epilepsy

目的:研究选择性海马切除术后难治性癫痫患者个性特征的变化。方法:回顾性分析52例癫痫患者在选择性海马切除术前、术后1年行艾森克个性问卷(EPQ)测评,观察相应测量指标变化。结果:52例选择性海马切除患者术后EPQ中精神质(P)、内外向(E)、神经质(N)分值较术前下降(P<0.05);23例行左侧海马切除患者术后P、E、N分值也较术前下降(P<0.05),而29例行右侧海马切除者术前术后1年P、E、N分值无明显差异(P>0.05);Engle分级Ⅰ～Ⅱ级患者术后P、E、N分值均较术前有明显差异(P<0.05),Ⅲ～Ⅳ级患者术后P、E、N无明显改变(P>0.05)。结论:一侧选择性海马切除术后患者个性可能发生改变,且左侧较右侧影响较大,术后1年内症状控制优良者较控制差或无效者个性变化大。

Objective：To evaluate the effects of selective resection of hippocampu on personal characteristic variation of patients with intractable epilepsy.Methods：Tweenty three patients who received left resection of hippocampu（LRP）and tweenty nine ones who did right resection of hippocampu（RRP）were tested by the revised Eysenck Personality Questionnaire（EPQ）before and one year after the surgical operation.Results：P,E and N scores of all patients after the treatment were significantly lower than those before the treatment（P〈0.05）.A significant decrease of postoperational P,E and N scores was found in LRP group（P〈0.05）,but not found in RRP group.P,E and N scores of the patients with Engle class Ⅰand Ⅱafter the operation were lower than those before the operation（P〈0.05）,but these scores did not changed significantly in the patients with Engle class Ⅲ and Ⅳ.Conclusion：Selective resection of hippocampu has effects on personal characteristic and LRP is of more effects than RRP.