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软骨代谢标志物COMP对骨关节炎软骨改变的反应 被引量：12

Metabolic Change of Cartilage Reflected by Cartilage Oligomeric Matrix Protein
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摘要 目的研究血清中软骨寡聚基质蛋白(cartilage oligomeric matrix protein,COMP)水平与骨关节炎病变严重程度的关系。方法采用ELISA方法测定正常对照组和22例骨关节炎患者血清中及关节液中的COMP水平。结果骨关节炎患者血清中COMP水平明显高于正常组水平,有统计学差异。结论血清中COMP水平与骨关节炎病变严重程度相关,测定骨关节炎患者血中COMP水平对进一步研究OA发病机理及早期发现骨关节炎并采取有效防治策略,监测防治效果具有极其重要的意义。 Objective To investigate the relationship between the levels of COMP in serum and severity of osteoarthritis. Methods Serum samples of 22 patients with osteoarthritis and 40 normal persons in controls were collected. Serum levels of COMP were analysed using Enzyme-linked immunosorbent assay （ELISA）. Results Serum- COMP levels of osteoarthritis patients were higher than those in control group（P〈0. 05）. Conclusion The serum levels of COMP is related with the grade of destruction of osteoarthritis cartilage. COMP is the sensitive marker reflecting the metabolic changes of articular cartilage.
作者 刘志伟 严伟洪 孙晓亮 朱江 罗光华 徐宁
机构地区 江苏省常州市第一人民医院
出处 《实用骨科杂志》 2007年第8期469-471,共3页 Journal of Practical Orthopaedics
关键词 骨关节炎 COMP 酶联免疫吸附测定 osteoarthritis COMP enzyme-linked immunosorbent assay
分类号 R684.3 [医药卫生—骨科学]
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参考文献13

  • 1Crnkic M,Mansson B,Larsson L,et al.Serum cartilage oligomeric matrix protein(COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept[J].Arthritis Res Ther,2003,5(4):181-185.
  • 2Hedbom E,Antonsspon P,Hjerpe A,et al.Cartilage matrix proteins.An acidic oligomeric protein (COMP) detected only in cartilage[J].J Biol Chem,1992,267(9):6132-6136.
  • 3Larsson E,Erlandsson HH,Lorentzen JC,et al.Serum concentrations of cartilage oligomeric matrix protein,fibrinogen and hyaluronan distinguish inflammation and cartilage destruction in experimental arthritis in rats[J].Rheumatology(Oxford),2002,41(9):996-1000.
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  • 5Garnero P,Piperno M,Gineyts E,et al.Cross sectional evaluation of biochemical markers of bone,cartilage,and synovial tissue metabolism in patients with knee osteoarthritis:relations with disease activity and joint damage[J].Ann Rheum Dis,2001,60(6):619-626.
  • 6Joosten L,Helsen MM,Saxne T,et al.IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type Ⅱ collagen-induced arthritis,whereas TNF-alpha blockade only ameliorates joint inflammation[J].J Immunol,1999,163(9):5049-5055.
  • 7Dragomir AD,Kraus VB,Renner JB,et al.Serum cartilage oligomeric matrix protein and clinical signs and symptoms of potential pre-radiographic hip and knee pathology[J].Osteoarthritis Cartilage,2002,10(9):687-691.
  • 8姚力,周乙雄,赵丹慧,尹大庆,张洪,康倩,薛延.软骨代谢标志物对骨关节炎软骨改变的反映[J].中华骨科杂志,2002,22(12):705-708. 被引量：10
  • 9姚力,周乙雄,赵丹惠,黄靖香,薛延.骨关节炎软骨中Ⅰ型和Ⅱ型胶原的分布[J].中国矫形外科杂志,2002,9(2):167-169. 被引量：8
  • 10Vilim V,Olejarova M,Machacek S,et al.Serum levels of cartilage oligomeric matrix protein(COMP) correlate with radiographic progression of knee osteoarthritis[J].Osteoarthritis Cartilage,2002,10(9):707-713.

二级参考文献19

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实用骨科杂志
2007年 第8期

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