蛛网膜下腔出血后脑血管痉挛患者中vWF水平的观察

Observation of the level of von willebrand factor in cerebral vasospasm patients after subarachnoid hemorrhage

目的观察蛛网膜下腔出血后脑血管痉挛(CVS)患者血浆中血管性血友病因子(Von Willebrand factor,vWF)的水平。方法观察蛛网膜下腔出血后脑血管痉挛发作<72 h、1 w、2 w血浆vWF的水平,采用ELISA法测定vWF含量。结果缺血性脑卒中、蛛网膜下腔出血后脑血管痉挛患者的vWF水平高于对照组(P<0.05)。脑血管痉挛患者vWF高于脑卒中组。结论vWF水平的检测可以作为蛛网膜下腔出血后脑血管痉挛诊断的一个标志物。

Objective To observe the change of the level of von willebrand factor （vWF） in cerebral vasospasm patients plasma after subarachnoid hemorrhage.Methods To observe the level of vWF in plasma at 〈 72 h,1 w,2 w attack of cerebral vasospasm after subarachnoid hemorrhage, vWF content was examined by ELISA. Results The levels of vWF in the patients with ischemic stroke, cerebral vasospasm after subarachnoid hemorrhage were higher than control group（ P 〈 0.05） and cerebral vasospasm group was higher than stroke group. Conclusion vWF can be useful for diagnoses of cerebra/vasospasm after subarachnoid hemorrhage as a marker.