GnRH-R在子宫内膜异位症中的表达及其临床意义

Expression of the GnRH-R in Endometriosis

目的研究促性腺激素释放激素受体(GnRH-R)在子宫内膜异位症(内异症)异位及在位内膜组织中的表达,探讨其与内异症的关系,为临床诊治内异症提供理论依据。方法选择内异症异位内膜30例,并取其中在位内膜组织30例,另选正常子宫内膜组织30例作为对照组,应用免疫组织化学的方法检测上述组织中GnRH-R的表达,分析其与内异症的关系。结果GnRH-R在内异症异位内膜及在位内膜组织中表达,分别为66.67%,100%,差异有显著性(P<0.005),其相对表达量均明显高于正常子宫内膜(16.67%),差异均有显著性(P<0.005)。结论GnRH-R在内异症异位内膜、在位内膜的表达差异可能与内异症的发生、发展有关,借此可更有效地利用促性腺激素释放激素类似物治疗子宫内膜异位症。

Objective To investigate the expression of the GnRH-R in the eutopic endometrium and ectopic endometnum tram women with endometrium, and to discuss its clinical significance. Methods Biopsies 30 cases with ectopie endometrium, including 30 cases eutopic endometrium from women with endometrium, were examed for expression of GnRH-R using immunohistochemical techniques. Normal endometrium tissues from 30 patients with uterine fibroid were used as control. Results There was significant difference between the eutopie and eetopie endometrium in expression of GnRH-R（66.67%, 100%, P 〈 0. 005 ）;The relative expression amousts of GnRH-R in the eutopic and eetopie endometrium of the patients with endometriosis（100%, 66.67%） both were higher than those in the normal endometrium （ 16.67 % ） （ P 〈 0.01, P 〈 0. 005 ）. Conclusion The expression of GnRH-R in the eutopic endometriosis and ectopic endometrium changes significantly, which may be associated with the pathogenesis and development of endometriosis, which will be helpful to treat endometriosis with GnRH-a.