基于Bayes推断的基因芯片探针特异性估计模型

Probe specificity estimation model based on Bayes theory

序列相似性计算是生物信息处理中的基本问题。针对基因芯片设计中的特异性评价问题,基于Bayes推断,建立了DNA序列快速估计算法,该算法不需要序列联配(alignment-free),性能好于广泛应用的相似性计算工具,可以大幅提高基因芯片设计性能。

Sequence similarity is one of the pivotal problems in field of bioinformatics.This paper proposes a fast DNA sequence similarity estimation method based on Bayes theory. The algorithm is alignent-free,outperformances current similarity alignment algorithms,and can greatly improve the performance of Gen Chip design.