摘要
利用放射免疫法分析观察了40例新生儿肺炎的血浆内皮素变化。结果显示肺炎患儿血浆内皮素水平明显高于正常新生儿，差异有显著性。重症肺炎内皮素水平又高于轻型肺炎，有心衰患儿高于无心衰者，差异均有显著性。内皮素有强烈的缩血管效应，使肺小动脉痉挛，产生肺动脉高压，本组病例肺炎病情越重，其体内内皮素水平越高，提示内皮素在新生儿肺炎并心衰的发病机理中起重要作用。
The levels of plasma endothelin in 40 cases with pneumonia and 20 normal newborns were determined by radio immunoassay. Among the 40 cases, 13 were general penumonia,27 were severe and 12 were complicated with heart failure. We found that the endothelin lev els both in general and severe pneumonia cases were significantly higher than that in normal newborns, and the levels of severe group were also significantly higher than the general group. 12 heart failure cases showed the highest endothelin level. The results suggest that endothelin may play a role in the pathophysiological mechanisms of heart failure in neonatal pneumonia and have some relation to the severity of pneumonia
出处
《新生儿科杂志》
1997年第1期5-6,共2页
The Journal of Neonatology
