摘要
目的:研究养血清脑颗粒对血管痉挛期的蛛网膜下腔出血(SAH)动物模型脑血流的影响。方法:枕大池注射尾动脉血建立大鼠SAH血管痉挛期模型,灌胃喂食不同剂量养血清脑颗粒,并采用激光多普勒仪测定其对鼠脑脑血流的影响。结果:不同剂量组给药后脑血流改变率差异有显著性,具有统计学意义。结论:养血清脑颗粒可以在血管痉挛期改善SAH鼠脑的脑血流供应,并存在一定的剂量相关性。
OBJECTIVE： To study the effects of Yangxue Qingnao Granula on cerebral blood flow in subarachnoid hemorrhage （SAH） model rats during angiospasm. METHODS： The cisterna magna of rats were injected with arteria caudilis blood to establish SAH model （during angiospasm） ;then the rats were administered intragastrically with different dosage of Yangxue Qingnao Granula, and the effects of which on cerebral blood flow in rats were detected by laser - Doppler. RESULTS： There were significant differences in cerebral blood flow improvement rate among different dosage groups. CONCLUSION： Yangxue Qingnao Granula can dose - dependently improve the cerebral blood flow in SAH model rats during angiospasm.
出处
《中国医院用药评价与分析》
2007年第4期308-309,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
养血清脑颗粒
蛛网膜下腔出血
脑血流
Yangxue Qingnao Granula
Subarachnoid hemorrhage
Cerebral blood flow
