垂体瘤海绵窦侵袭性与CD34和PTTG表达的关系

Expression of CD34 and PTTG relates to pituitary adenomas with invasion of the cavernous sinus space

目的:探讨海绵窦侵袭性垂体腺瘤的CD34和垂体瘤转化基因(pituitary tumor transforming gene,PTTG)表达特点。方法:收集62例手术治疗的垂体大腺瘤患者资料,按照Knosp标准对肿瘤进行分组,对标本行CD34和PTTG免疫组化染色检查,对染色结果进行统计学比较。结果:62例患者中海绵窦侵袭二级以上者共23例,微血管密度(MVD)平均值为44.04,PTTG超过(++)为71.4%(15/21),海绵窦侵袭二级和二级以下者共39例,MVD平均值为33.12,PTTG超过(++)为30.6%(11/36),χ2检验两者差异有统计学意义(P<0.05)。结论:海绵窦侵袭超过Ⅱ级的垂体腺瘤其微血管密度大,PTTG表达强度高,肿瘤具有较强的侵袭性,手术全切困难,术后易复发,术后应给予放射治疗或是药物辅助治疗。

Objective： To investigate the characteristics of CD34 and PrIG expression in pituitary adenomas with invasion of Re cavernous sinus space. Methods： Sixty-two patients with large pituitary adenomas were divided into groups based on the Knosp criteria. Expression of CD34 and PTrG was determined by immunohistochemical method. Resuits： The mean microvascular density （MVD） of tumors which surpassed the latemal marginal level of ICA was 44.04, and their PTrG exceeding （ ＋＋ ） ranked 71.4%（15/21）. And, the mean MVD of tumors within the latemal marginal level of ICA was 33.12, and the PTIG that exceeding （ ＋ ＋ ） ranked 30.6% （11/36）. There were statistical differences between the two groups （ P 〈 0.05）. Conclusion： Pituitary adenomas surpassing the latemal marginal level of ICA have strong expression of MVD and P＇ITG and strong invasiveness, so they are difficult to remove completely and should be treated with radiotherapy or drugs after surgery.