结直肠癌根治术后复发转移相关因素分析

Recurrence-related factors following curative surgery for colorectal cancer

目的：探讨结直肠癌根治术后复发转移的相关临床病理因素。方法：应用χ2和logistic回归分析方法,回顾性分析我院1996-2006年结直肠癌根治术后1年以内早期复发的120例患者与同期3年以内未复发72例患者的临床病理资料。结果：χ2检验结果显示,肿瘤部位、淋巴结转移、术后辅助化疗情况、肠壁侵润深度和Dukes′分期两组之间比较差异有统计学意义（P〈0.01）。单因素回归分析显示,淋巴结转移、肠壁浸润深度、分化程度、术后是否联合辅助化疗与复发转移有关。多因素回归分析显示,淋巴结转移、肠壁浸润深度是复发转移的危险因素。结论：淋巴结转移、肠壁浸润深度是影响结直肠癌术后复发转移重要的预后因素。

Objective： To investigate the clinicopathologic factors relating to recurrence following curative surgery for colorectal cancer. Method： The clinicopathologic data of 120 cases with early recurrence within one year and 72 cases without recurrence within three years from 1996 to 2006 were retrospectively analyzed by Z2 and logistic regres- sion methods. Results： Z2 analysis showed that tumor localization, lymph node metastases status, pest-operative adju- vant chemotherapy, the Dukes.＇ stage and the depth of invasion of the bowel wall were all significantly different between the two groups. Univariate analysis also showed that the lymph node metastasis, depth of bowel wall invasion, histological differentiation and associated adjuvant chemotherapy after operation were significantly associated with recurrence and me- tastasis of operation. Multivariate analysis showed that lymph node metastasis and depth of bowel wall invasion were risk factors for recurrence and metastasis. Conclusion： Lymph node metastasis and depth of bowel wall invasion are important prognostic factors for recurrence and metastasis after colorectal cancer surgery.