MEBO对烧伤患者的免疫学影响

The Effect of MEBO on the Immunity of Burn Patients

本文从局部及全身免疫方面对120例烧伤患者进行了研究，尤其对60例MEBO治疗患者，局部及全身IgA、IgG、IgM产生细胞和C3的变化进行了检测。结果显示：①烧伤区免疫因子染色强度均明显高于正常人及非烧伤区（P<0.01）。②烧伤深度及面积与局部免疫因子染色强度呈正相关，烧伤越深及面积越大，患者局部免疫因于染色越强，免疫力则高（P＜0．05）。③MEBO治疗，不同程度烧伤患者的痊愈时间明显较对照组缩短（P＜0．01），MEBO有明显促进烧伤创面愈合作用。④MEBO治疗后患者局部免疫因子染色强度明显高于治疗前及对照组（P<0．05），MEBO有明显提高烧伤患者局部免疫功能作用。⑤MEBO治疗后患者周围血和血清免疫球蛋白明显高于治疗前及对照组（P<0．05），MEBO有明显提高烧伤患者全身免疫功能作用。⑥MEBO治疗局部感染率明显低于对照组（P<0．05），MEBO有明显抗感染作用。并研究探讨了MEBO治疗中疗程与局部免疫、烧伤深度与局部及全身免疫、烧伤面积与局部及全身免疫间的关系。证实，MEBO可通过提高患者机体免疫力，对抗细菌、病毒及毒素对烧伤创面的侵袭，起到控制烧伤创面感染作用，且通过提高机体免疫力，促进创面愈合。

This paper reports the study of local and sysytemic immunplogical reaction of 120 cases of burn, especially the results of 60 cases treated with MEBO. Changes in local and systemlc lgA, lgG, lgM producing cell and C3 were monitored. The results revealed that:1. The staining strength of immune factor in burn site is significantly higher than that in non-burn site and in healthy people. (P<0.01).2. The depth and the area of burnhave a positive correlation with the local immune factor staining strength. The deeper and the larger the burn wound,the higher the staining strength of the local immune factor and the higher the immunity. (P<0.05).3. MEBO shortened the healing period of patients with different degrees of burn. Compared with nonMEBO control. The difference is significant. (P<0.01). MEBO has healing promoting effect.4. Patients treated with MEBO had their local immune factor staining strengthh higher than those treated with non-MEBO method. (P<0.05).5. Patients treated with MEBO had their peripheral blood and serum immunoglobulin higher than before MEBO treatment and also higher than those treated with non-MEBO method. (P<0.05). MEBO significantly promoted immunity.6. Local infection rate of the patients treated with MEBO was significantly lower than that of those treated with non-MEBO method. (P<0.05). MEBO had antiinfective effect.The relation between the changes in local and systemic immunity and the depth and the area of burn is also investigated.