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血管内皮生长因子及其受体在单侧输尿管梗阻大鼠术侧肾脏的表达

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摘要 血管内皮生长因子(VEGF)的主要作用是刺激血管内皮细胞的增殖与分化、抑制内皮细胞凋亡,主要通过两个受体Flk-1和Flt-1发挥作用。本研究旨在明确VEGF及其受体在单侧输尿管梗阻(UUO)大鼠术侧肾脏不同时间的表达变化情况,为进一步探讨其在UUO大鼠小管间质纤维化中的作用机制提供实验依据。
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2007年第8期544-545,共2页 Chinese Journal of Nephrology
基金 国家自然科学基金(30400210) 上海市科委基础研究重点课题(03jc14084) 上海市启明星追踪计划(04QMH1401)
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  • 1Flyvbjerg A.Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease.Diabetologia,2000,43:1205-1223.
  • 2Yancopoulos GD,Davis S,Gale NW,et al.Vascular-specific growth factors and blood vessel formation.Nature,2000,407(6801):242-248.
  • 3Abdulmalek K,Ashur F,Ezer N,et al.Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats.Am J Physiol Lung Cell Mol Physiol,2001,281:L582-L590.
  • 4Yamamoto Y,Maeshima Y,Kitayama H,et al.Tumstatin peptide,an inhibitor of angiogenesis,prevents glomerular hypertrophy in the early stage of diabetic nephropathy.Diabetes,2004,53:1831-1840.
  • 5Osterby R,Asplund J,Bangstad HJ,et al.Neovascularization at the vascular pole region in diabetic glomerulopathy.Nephrol Dial Transplant,1999,14:348-352.
  • 6Satchell SC,Mathieson PW.Angiopoietins:microvascular modulators with potential roles in glomerular pathophysiology.J Nephrol,2003,16:168-178.
  • 7Padro T,Ruiz S,Bieker R,et al.Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia.Blood,2000,95:2637-2644.
  • 8Khamaisi M,Schrijvers BF,De Vriese AS,et al.The emerging role of VEGF in diabetic kidney disease.Nephrol Dial Transplant,2003,18:1427-1430.
  • 9Thurston C,Suri C,Smith K,et al.Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1.Science,1999,286(5449):2511-2514.
  • 10Enholm B,Paavonen K,Ristimaki A,et al.Comparison of VEGF,VEGF-B,VEGF-C and Ang-1 mRNA regulation by serum,growth factors,oncoproteins and hypoxia.Oncogene,1997,14:2475 -2483.

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