NB-UVB联合派瑞松乳膏治疗掌跖脓疱病的疗效观察

Efficacy of narrowband ultraviolet B phototherapy in combination with pevisone in the treatment of pustulosis palmaris et plantaris

目的:评价窄谱中波紫外线(NB-UVB)联合派瑞松局部治疗掌跖脓疱病的疗效。方法:采用随机、开放、平行、对照性试验。67例掌跖脓疱病患者被随机分为3组:治疗组予NB-UVB局部照射,1次/3d,派瑞松涂患处2次/d;对照组分别单独给予NB-UVB(UVB组),或给予派瑞松(P组)用法同上。2周为1个疗程。分别于治疗前、治疗后每2周评定患者的症状积分下降指数(SSRI)。结果:共有63例患者完成试验,治疗组2周、4周时SSRI显著高于UVB组(均P<0.05),与P组(均P<0.01);治疗组痊愈率2周时为28.0%,4周时为52.0%,均显著高于UVB组与P组(P<0.01)。总有效率治疗组在2周与4周时均为92.0%,与UVB组及P组比较,无统计学差异。结论:NB-UVB联合派瑞松外用治疗掌跖脓疱病具有较好的疗效。

Objective： To evaluate the efficacy of narrowband ultraviolet B （NB- UVB） phototherapy combined with pevisone in the treatment of pustulosis palmaris et plantaris. Methods： Sixty- seven patients were divided into three groups. The patients either received NB- UVB phototherapy, once every three days, plus topical pevisone, twice a day （treatment group）, or received NB - UVB phototherapy, once every three days （UVB group）, or were treated with topical pevisone twice a day （pevison group）. Symptom score reducing index （SSRI） were evaluated in each group before and every 2 weeks after treatment. Results： Sixty - three patients completed the trial. SSRI after 2 and 4 weeks were significantly higher in treatment group than UVB group （ P 〈 0.05） and pevison group （ P 〈 0.01）. The cure rate in the treatment group was 28.0% after 2 weeks and 52.0% after 4 weeks, which were significantly higher than that in UVB group. The total response rate in the treatment group was 92.0% both after 2 and 4 weeks, which were no significant difference compared with UVB group and pevison group （both P 〉 0.05）. Conclusion： The results suggest that the combined NB- UVB phototherapy with pevisone in the treatment of pustulosis palmaris et plantaris has higher cure rate.