老年人血浆溶血磷脂酸和磷脂酸水平综合干预后的效果比较

Plasma lysophosphatidic acid and phosphatidate levels in the elderly: Comparison before and after combined intervention

目的:通过对老年人进行血浆溶血磷脂酸和磷脂酸的筛检,从而认识血浆溶血磷脂酸和磷脂酸在血栓预防中的作用。方法:对2004-04/07期间的1657名和2005-04/07期间的1748名离休干部进行血浆溶血磷脂酸和磷脂酸含量测定,并对溶血磷脂酸>3.0μmol/L和磷脂酸>5.0μmol/L的阳性人员进行药物干预。同时,选择2004年溶血磷脂酸和/或磷脂酸阳性人员119人,随机分为两组:①干预组(n=72):男63人,女9人,平均年龄78岁。口服阿司匹林100mg/d,持续1个月。②对照组(n=47):男42人,女5人,平均年龄76岁。干预后,测定两组血浆中溶血磷脂酸和磷脂酸的含量。结果:纳入对象全部进入结果分析。2005年磷脂酸及血浆溶血磷脂酸+磷脂酸阳性率均明显低于2004年(P<0.01),尤其是磷脂酸的阳性率降低的更为明显。2005年血浆溶血磷脂酸和磷脂酸的平均值均明显低于2004年(P<0.01)。干预组干预后血浆溶血磷脂酸和磷脂酸明显低于干预前及对照组(P<0.01)。结论:①血浆溶血磷脂酸和磷脂酸的测定可作为血栓预警和了解抗血栓药物疗效的一种手段。②阿司匹林干预后,血浆溶血磷脂酸和磷脂酸的含量均降低,可作为一种降低缺血性疾病发生率的有效途径。

AIM： To confirm the preventive effects of plasma lysophosphatidic acid （LPA） and phosphatidate （PA） on thrombosis by screening LPA and PA in the elderly. METHODS= Determination of LPA and PA contents in 1 657 retired veteran officials between April and July 2004 and 1 748 retired veteran officials between April and July 2005 was carried out respectively, and the subjects with LPA 〉 3.0 μmol/L and PA 〉 5.0 p.mol/L positive were treated with medication. Meanwhile, 119 subjects with LPA and/or PA positive were selected in 2004 and randomly divided into two groups： ①lntervention group （n =72） including 63 males and 9 females, average age of 78 years, oral administration of aspirin, 100 mg daily for 1 month. ②Control group （n =47） including 42 males and 5 females, average age of 76 years. LPA and PA contents in both groups were detected after intervention. RESULTS： All subjects were involved in the result analysis. There was a markedly lower positive rate of PA and LPA＋PA in 2005 than those in 2004 （P 〈 0.01）, particularly that of PA. The average values of LPA and PA contents in 2005 were lower than those in 2004 （P 〈 0.01）. After intervention, LPA and PA contents in the intervention group were markedly lower than those before intervention and in controls （P 〈 0.01 ）. CONCLUSION： ①Determination of LPA and PA contents can predict thrombosis and serve as an important method to confirm the effects of anti-thrombus therapies. ②There is a decrease in plasma LPA and PA following aspirin intervention, which serves as an effective means of decreasing the incidence of ischemic diseases.