腹腔镜下卵巢打孔术对PCOS患者激素水平的影响

Effects of Laparoscopic Ovarian Drilling on Serum Hormone Levels in PCOS Patients

目的观察腹腔镜卵巢电凝打孔术对多囊卵巢综合征患者性激素和胰岛素抵抗的影响。方法于2004年1月-2006年6月对30例耐药的多囊卵巢综合征患者进行腹腔镜下卵巢电凝打孔术治疗,观察手术前后患者性激素水平和空腹血糖、空腹胰岛素水平的变化。结果30例患者术后LH、T和E2较术前明显降低(P<0.01),而FSH、PRL、FBG、FINS无明显变化(P>0.05)。结论腹腔镜卵巢电凝打孔术有利于卵巢功能的恢复和排卵,但并非通过改善胰岛素抵抗起作用。

Objective To evaluate effects of laparoscopic ovarian drilling （LOD） on serum sex hormone levels and insulin resistance in polycystic ovary syndrome （PCOS） patients. Methods 30 women with PCOS who were in clomiphene -resistant anovulatory were treated by LOD between 2004 and 2006. Patients attended for blood sampling to measure the serum concentration of FSH, LH, T,E2,PRL, FBG, FINS before and after LOD. Results There was a significant reduction in serum testosterone, LH, E2 levels after surgery（ P 〈 0.01 ）, the levels of PRL, FSH, FBG and FINS were not significantly different after treatment（ P 〉 0.05）. Conclusion LOD was of benefit to resuming ovary function and ovulation, but not through ameliorating the insulin resistance.