结缔组织病并全身炎症反应综合征患者血清降钙素原检测的临床意义

Clinical Significance of Serum Procalcitonin Determination in Patients With Connective Tissue Disease Associating Systemic Inflammatory Response Syndrome

目的:了解血清降钙素原(PCT)在结缔组织病并全身炎症反应综合征(SIRS)患者中的检测意义。方法:50例伴SIRS未合并感染的结缔组织病(CTD)患者和40例伴SIRS的细菌感染患者,在临床出现炎症表现24h内测定血清PCT值。结果:伴SIRS的细菌感染组PCT值高于伴SIRS的未合并感染CTD患者(1.3±0.3)ng/mlvs(0.3±0.1)ng/ml。PCT对诊断细菌感染的敏感性为70%,特异性为96%,阳性预测值为93.3%,阴性预测值为80%。结论:PCT值在患结缔组织病并SIRS时一般不升高,但合并细菌感染时PCT水平可明显增高,对感染性和非感染性全身炎症反应综合征具有一定的鉴别诊断意义。

Objective： To understand the clinical significance of serum procalcitonin （PCT） in patients with connective tissue disease （CTD） associated with systemic inflammatory response syndrome（SIRS）. Methods： Fifty CTD patients with non-infectious SIRS and 40 patients with bacterial infections and SIRS were enrolled in the study. The serum PCT were determined within 24 hours after clinical onset of SIRS. Results： Serum PCT tended to be significantly higher in infections and SIRS group than that in the non-infectious SIRS group [（1.3 ± 0. 3）ng/ml vs （0. 30 ± 0. 1）ng/ml]. PCT has the sensitivity （70%）, specificity （96%）, positive predict （93. 3%）, negative predict （80%） for bacterial infection. Conclusion： PCT is often normal in CTD patients with SIRS, but it may significantly increase when these patients accompany bacterial infection. PCT might be an effective indicator to differentiate infectious from non-infectious SIRS.