心脏手术前后心肌肌钙蛋白T和心肌酶谱的变化

The significance of changes in serum cardial troponin T and myocardial enzyme in affiliated myocardial injury

目的:探讨血清心肌肌钙蛋白T(cTnT)和心肌酶谱在心肌手术损伤前后的变化及其临床意义。方法:动态观察20例二尖瓣膜置换术患者手术前、后2h血清cTnT和心肌酶谱的变化。结果:二尖瓣膜置换术患者血清cTnT含量、心肌酶谱活性在术后2～24h较术前显著升高(P<0.01),其中血清cTnT含量术后2h增加倍数高于其他指标。结论:血清cTnT含量、心肌酶谱活性均对心肌损伤的诊断有意义,但cTnT的心肌特异性及早期灵敏度更高,cTnT后期峰值对心肌损伤的预后判断有重要价值。

Objective To evaluate the significance of changes in serum cardiac troponin T（cTnT） and myocardial enzyme in myocardial injuried patients.Methods In twenty patients underwent mitral vavle replacement（MVR）,serum cTnT and myocardial enzyme spectrum levels were measured before operation, 2-24 hour after operation. Results Compared with patients before MVR operation,the serum cTnT and myocardial enzyme spectrum levels at 2-24hour after MVR opration increased significantly （P〈0.01）,and serum cTnT concentrations at 2 hour after opration increased more times than other indexes. Conclusion Both serum cTnT and myocardial enzyme spectrum levels can serve as useful markers to reflect myocardial injury,hut cTnT appears to he more specific and sensitive than myocardial enzyme spectrum.The delayed higher peak of cTnT has an important reference value to predict the prognoses of myocardial injury.