月经卡评分估计子宫出血的有效性及其在临床研究中的应用

Effectiveness and Clinical Application of Pictorial Chart in Estimation of Menstrual Blood Loss

目的:评价月经卡评分用于估计子宫出血的有效性,并将之应用于评价妥塞敏预防育龄妇女放置IUD后子宫异常出血的疗效。方法:采用双盲的临床试验方法,将研究对象随机分配到妥塞敏全剂量组、半剂量组和安慰剂组,放置统一的IUD,记录月经卡评分,同时用碱性正铁血红蛋白法测定经血量。结果:月经卡评分与碱性正铁血红蛋白法测定结果存在高度相关性(r=0.612,P<0.001);ROC曲线下面积为0.775,以138分作为确定月经过多的合适界值,此时的灵敏度为77.3%,特异度为76.2%。评价妥塞敏预防放置IUD后子宫异常出血效果时,两法结果类似。结论:月经卡评分可有效估计子宫出血量,判断月经过多。

Objective： To assess the effectiveness and application of pictorial chart in estimation of menstrual blood loss（MBL） and evaluating the preventive effect of transamin on MBL after insertion of IUD, respectively. Methods： A randomized, double -blind clinical trial was conducted in eligible women who were as- signed into full - dose group, half - dose group and placebo group, and were inserted unified IUDs. Both the score of pictorial chart and alkaline hematin method were applied to estimate MBL. Results： The score of pictorial chart was highly correlated with the MBL measured by alkaline hematin method （r =0.612, P 〈0. 001 ）. The area under the ROC curve was 0.775 and a cut - off point at 138 was acceptable for diagnosis of menorrhagia at which the sensitivity was 77.3% and the specificity was 76.2%, respectively. The results of the two methods were similar when they were applied to assess the preventive effect of Trunsamin on MBL after insertion of IUD. Conclusion ： The pictorial chart is effective to estimate the amount of MBL which can diagnose menorrhagia.