胆舒通片对胆道系统作用的实验研究

Pharmacological Study of Danshutong Tablets on the Biliary System

目的观察胆舒通片的利胆、镇痛、抗炎作用。方法用BL-410生物实验系统测定家兔胆囊运动,胆汁流量、Odd i括约肌紧张性和胆道末端内压,并采用相应的药理学模型研究胆舒通片的抗炎、镇痛作用。结果胆舒通片能增加胆囊收缩曲线下面积,显著增加家兔胆囊收缩的频率和收缩幅度,表明胆舒通片有增强胆囊收缩的作用。胆舒通片能促进胆汁分泌,可降低胆道末端内压,具有松弛Odd i括约肌的作用。可提高小鼠的热刺激痛阈,减少醋酸引起的扭体次数;对蛋清性足跖肿胀及对二甲苯引起的耳廓肿胀均有抑制作用,降低毛细血管通透性。结论胆舒通片具有利胆、抗炎、镇痛作用。

OBJECTIVE To observe the cholagogic, analgesic and antiinflammatory effects of danshutong tablets. METHODS The bile circulation,the tensity of sphincter of Oddi and the gallbladder contractibility of rabbits were determinated, the analgesic and antiinflammatory actions were studied on the corresonding pharmacogical models. RESULTS Danshutong tablets significantly increased the frequency, amplitude, and the area under curve （AUC） of rabbit gallbladder contractibility and the bile circulation,it also relaxed the sphincter of Oddi. Danshutong tablets could enhance mouse pain threshold, and decrease the number of mouse torsive posture. Danshutong tablets inhibited the swollen of rat metatarsuses by the egg white and the swollen of mouse ears by dimethylbenzene. Danshutong tablets could reduce the capillary permeability of mouse skin and abdomen. CONCLUSION Danshutong tablets had the effects of cholagogic, analgesic and anti-inflammatory.