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银锌乳膏含量测定方法研究 被引量:1

Study on Determination Method of Mainly Ingredient in the Silver and Zinc Cream
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摘要 目的提出银锌乳膏中磺胺嘧啶银、磺胺嘧啶锌和磺胺嘧啶的含量测定方法。方法用永停滴定法测定磺胺嘧啶,富尔哈特法测定磺胺嘧啶银,计算法或配位滴定法测定磺胺嘧啶锌含量,并按药典规定从精密度、加样回收率和专属性方面对测定方法进行了验证。结果高、中、低三种浓度中磺胺嘧啶测定值的RSD<0.49%;磺胺嘧啶银测定值的RSD<0.79%;磺胺嘧啶锌计算值的RSD<1.2%,实际测定5份中浓度,RSD为0.66%。加样回收率试验测定结果,磺胺嘧啶为100.18%、磺胺嘧啶银为98.68%、磺胺嘧啶锌为98.70%。结论试验结果表明,拟订的方法用于本乳膏的测定,操作简单,结果可靠。 OBJECTIVE To improve assaying method of the contents of sulfadiazine, sulfadiazine silver and sulfadiazine zinc in the Silver and Zinc Cream (SZC). METHODS Mainly ingredient in the Silver and Zinc Cream were assay ied, sulfadiazine was measured by dead-stop titration, sulfadiazine silver determined by Volhar'method, sulfadiazine zinc was measured by calculate method or coordinate titration. Moreover, according to the demands of Chinese Pharmacopoeia (ChP) 2005, Appendix XIX A, the assaying method, except calculate method, being improved was tested from precision, rate of recovery and special. RESULTS The precision of five samples being classed as high, middle and low levels were determined. The relative standard deviation (RSD) of three levels of sulfadiazine, sulfafiazine silver and sulfadiazine zinc were less than 0.49%, 0.79% and 0.66%, respectively. The RSD of sulfadiazine zinc by calculate method was 1.2%. The recovery for middle level was 100.15% for sulfadiazine, 95.65% for sulfadiazine silver and 98.70% for sulfadiazine zinc,respectively. CONCLUSION The results of test shows that the present method is feasible, reliable, and accurate for the determination of main ingredients in the SZC.
出处 《中国现代应用药学》 CAS CSCD 北大核心 2007年第4期317-319,共3页 Chinese Journal of Modern Applied Pharmacy
关键词 磺胺嘧啶银 磺胺嘧啶锌 磺胺嘧啶 银锌乳膏 验证 sulfadiazine silver sulfadiazine zinc sulfadiazine cream test
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参考文献3

  • 1Ch.P(2005)Vol Ⅱ(中国药典2005年版.二部)[S].2005.
  • 2LIU W Y Compile.Pharmaceutical Analysis(药物分析)[M].Vol 4.Beijing:People Mdical Publishing House,2001:72-75.
  • 3DIAOYC LIJ CHENZY.Improve of assay method of content for sulfadiazine silver cream.药品检验,2000,9(1):34-34.

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