加替沙星在老年社区获得性肺炎患者体内的临床药动学研究

Clinical Pharmacokinetics of Gatifloxacin in Elder Community-acquired Pneumonia

目的研究加替沙星在老年社区获得性肺炎患者(community-acquired pneumonia,CAP)体内的药动学特征。据此拟订其用于老年CAP患者的给药方案。方法以HPLC测定患者口服加替沙星片(400 mg)后体内的血药浓度。结果受试者单剂口服400 mg加替沙星片后,体内血液分布符合二室开放模型,血药峰浓度cmax(2.83±1.13)mg.L-1、CL值(10.47±7.60)L.h-1低于健康人群,而达峰时间tmax(3.30±0.93)h、消除半衰期t1/2β(10.1±4.47)h、AUC(6.9±19.5)mg.h.L-1均较健康人群长,个体间参数差异较大。结论在给老年CAP患者使用加替沙星片时应注意给药剂量和给药间隔,慎重给药。

OBJECTIVE To study the clinical pharmaeokineties of gatifloxaein in elder community-acquired pneumonia（CAP） and draw up the dosage reqiment for the treatment of baeterial infeetions. METHODS After 400 mg gatifloxaein were administered orally to volunteers, serum concentrations of gatifloxaein were detected by HPLC. RESULTS The concentration-time date after single oral dose of 400 mg gatifloxaein fitted a two-eompartment open model, the peak serum eneentration Cmax （2. 83 ± 1. 13 ）mg· L^- 1 and CL （ 10.47 ±7.60） L· h^-1 are lower than healthy volunteers,t1/2β （ 10. 1 ±4.47） tmax（3.30 ±0.93） h and AUC（46.9 ± 19.5） mg·h · L^-1 are longer than healthy volunteers with large differenee in individuals. CONCLUSION The dosage and administer distanee should be notieed when gatifloxaein is used for the elder CAP.