盐酸米多君片预防透析性低血压的临床观察

Clinical Observation of Midodrine Hydrochloride in Preventing Hemodialysis-related Hypotension

目的观察盐酸米多君片对透析过程中出现的低血压现象的预防效果,及对相关症状的缓解作用。方法对37例血液透析患者(1665人次),在透析前、透析1 h、透析2 h(餐前0.5 h)分别给予盐酸米多君片7.5,5,2.5 mg;观察透析前血压、透析中最低血压和透析后血压及临床症状的变化。结果经盐酸米多君片治疗后,低血压临床症状明显好转,典型症状、一般症状、轻微症状的人次与用药前比较均明显减少,差异均有显著性(P<0.01)。且透析前血压、透析中最低血压和透析后血压与用药前比较均有显著性差异(P<0.01),低血压得到控制,效果显著。结论盐酸米多君片对透析性低血压的预防及改善临床症状有显著疗效。

OBJECTIVE To observe the effect of midodrine hydrochloride to prevent hemodialysis-related hypotension and related symptoms. METHODS 37 patients （1665 hemodialysis procedures） were given midodrine hydrochloridedosage pre-, during, and post-hemodialysis, and the changes of blood pressure and clinical symptoms pre-, during, post-hemodialysis were observed. RESULTS The incidence of classic, usual, and slight symptoms were reduced significantly by using midodrine hydrochloride （P 〈 0.01 ）, Blood pressure pre-, during, post-hemodialysis was better controlled compare to pre-medicine therapy（ P 〈 0. 01 ）. CONCLUSION Midodrine hydrochloride is effective in preventing and improving clinical symptoms for the patients with hemodialysis-related hypotension.