摘要
目的探讨血清C-反应蛋白(C-reactive protein,CRP)水平与妊娠糖尿病(gestational diabetes mellitus,GDM)的关系。方法选取2002年6月至2006年6月本院门诊及住院患者经75g葡萄糖耐量试验(OGTT)确诊为妊娠期糖尿病患者(GDM)48例和糖耐量异常妊娠妇女32例,并随机选择同期相匹配的正常糖耐量妊娠妇女80例(作为对照组),同时检测空腹血清CRP水平。结果GDM组C-反应蛋白水平明显高于另两组(P<0.05);CRP水平与孕前体重指数(BMI)、空腹血糖、空腹胰岛素呈正相关,相关系数分别为0.348、0.156和0.296,P值分别为0.0001、0.0178和0.0004。直线回归方程y=0.0741x1+0.0147x2+0.0397x3-1.457,r2=0.2469。结论C-反应蛋白与GDM密切相关,参与了其发病机制。
Objective To investigate the relationship between C- reactive protein(CRP) and gestational diabetes mellitus (GDM). Methods We studied 160 healthy pregnant women undergoing oral glucose tolerance test. Based on oral glucose tolerance test and pre - pregnancy body mass index (BM1), participants were divided into three groups: 1 ) normal glucose tolerance (NGT) ( n = 80)as control ; 2) impaired glucose tolerance ( n = 32) ; 3 ) GDM ( n =48), the serum level Spearman correlation analysis and multivariate linear regression analysis was used, Results: CRP levels in GDM group were significantly higher than that of 1GT and NGT groups ( P 〈 0.01 ). CRP was significantly correlated with pre - pregnancy BM1 ( r = 0. 348, P 〈 0. 0001 ), followed by fasting blood glucose (r = 0.156, P = 0. 0178) and fasting insulin ( r = 0. 296, P = 0. 00046). In multivariate linear regression analysis, the ,same results were observed. Conclusion CRP might play a rule in pathogenesis of gestational diabetes mellitus.
出处
《浙江临床医学》
2007年第8期1030-1031,共2页
Zhejiang Clinical Medical Journal
关键词
妊娠糖尿病
C-反应蛋白
体重指数
Gestational diabetes mellitus C- reactive protein(CRP) body mass index