慢性支气管炎肺泡巨噬细胞释放6-酮-前列腺素F_(1α)和血栓素B_2的研究

CONSECUTIVE STUDY ON ALVEOLAR MACROPHAGE RELEASE OF 6 KETO PROSTAGLANDIN F 1α AND THROMBOXANE B 2 IN CHRONIC BRONCHITIS

１０例慢性支气管炎缓解期患者和１０例正常人的肺泡巨噬细胞（ＡＭ），加用ＬＰＳ体外培养。结果显示随着培养基中ＬＰＳ剂量增加，两组ＡＭ合成分泌的６－酮－前列腺素Ｆ１α（６－ｋｅｔｏ－ＰＧＦ１α）和血栓素Ｂ２（ＴＸＢ２）含量均逐渐增加。两组间存在显著差异性。表明慢性支气管炎缓解期患者ＡＭ更易活化释放这些炎性介质。

Alveolar macrophages(AM) obtained from 12 chronic bronchitis alleviation patients and 12 normal subjects were cultured with LPS.The percentage viability of AM after challenged with LPS from chronic bronchitis alleviation patients is less than that from normal subjects(P<0.05);with the amount of LPS increasing,AM elaborated and secreted more 6 keto PGF 1α ,thromboxane B 2;and a significant difference in the above mentioned inflammatory mediums existed between the two groups(P<0.05).Our findings showed that AMs from chronic bronchitis alleviation patients are easier to activate and release more inflammatory mediums,which may play a pivotal role in the pathogenesis of chronic bronchitis.