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胃肠间质瘤外科治疗32例

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摘要 目的分析胃肠间质瘤(GIST)外科治疗效果及其影响因素。方法回顾分析我院1999~2005年外科治疗的32例胃肠间质瘤临床和病理资料。结果本组术前均未能取得病理诊断。诊断依据术后病理及免疫组化检查。肿瘤发生部位:胃21例,小肠8例,直肠1例,肠系膜2例。肿瘤大小:≤5cm8例,>5cm24例。肿瘤的大小与良恶性相关(P<0.05)。生存率:术后1~、3~和5~年生存率分别为100%、81.3%和65.7%。局部完整切除和肿瘤及所在器官切除患者生存率之间比较,差异无显著意义(P=0.255)。结论1)GIST术前确诊困难,明确诊断主要依靠术后病理检查,CD117和CD34阳性可以作为GIST的诊断标志,而肿瘤的大小是判断良恶性的重要指标。2)手术切除是最有效的治疗手段。原则上施行局部完全切除即可,广泛切除或扩大淋巴结清扫不能提高生存率。
出处 《齐齐哈尔医学院学报》 2007年第11期1301-1303,共3页 Journal of Qiqihar Medical University
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参考文献10

  • 1Mazur MT,Clark HB.Gastric stromal tumors Rea ppraisal of histogenesis[J].Ann J Surg Pathol,1983,7(6):507-519
  • 2Meittinen M,Lasola J.Gastrointestinal stromal tumors definition,clinical,histological,immunohistochemical,and differential diagnosis[J].Virchows Arch,2001,438:1-12
  • 3万德森.提高对胃肠道间质瘤的认识[J].广东医学,2004,25(3):229-231. 被引量:26
  • 4Ando N,Goto H,Niwa Y,et al.The diagnosis of GI stromal tumors with EUS-guided fine needle aspiration with immunohistochemical analysis[J].Gastrointest Endosc,2002,55:37-43
  • 5DeMatteo B,Lewis JJ,Leung D,et al.Two hundred gastrointestinal seromal tumors;recurrence patterns and prognostic factors for survival[J].Ann Surg,2000,231:51-58
  • 6卢震海,万德森.胃肠道间质瘤的外科治疗[J].广东医学,2004,25(3):233-235. 被引量:26
  • 7许立功.胃肠道间质瘤化疗的过去、现在和将来[J].广东医学,2004,25(3):236-236. 被引量:10
  • 8Eisenberg BL,Judson I.Surgery and imatinib in the management of GIST:emerging approaches to adjuvant and neoadjuvant therapy[J].Ann Surg Oncol,2004,11(5):465-475
  • 9D'Amato G,Steinert DM,McAuliffe JC,et al.Update on the biology and therapy of gastrointestinal stromal tumors[J].Cancer Control,2005,12(1):44-56
  • 10Bauer S,Hartmann JT,de Wit M,et al.Resection Of residual disease in patients with metastatic gastrointestinal stromal tumors responding to treatment with imatinib[J].Int J Cancer,2005,117(2):316-325

二级参考文献19

  • 1Rossi CR, Mocellin S, Mencarelli R, et al. Gastrointestinal stromal tumors: from a surgical to a molecular approach. Int J Cancer,2003,107:171.
  • 2DeMatteo RP, Lewis J J, Leung D, et al. Two hundred gastrointestinal stromal tumor: recurrence patterns and prognostic factors for survival.Ann Srug,2000,231:51.
  • 3Eilber FC, Rosen G, Forscher C, et al. Recttrrent gastrointestinal stromal satcctnas. Surg Oncol,2000,9:71.
  • 4Mudan SS, Conlon KC, Woodruff JM, et al. Salvage surgery for patients with recurrent gastrointestinal sarcoma: prognostic factors to guide patient selection. Cancer, 2000,88:66.
  • 5Ng EH, Pollock RE, Munsell MF, et al. Prognostic factors influencing survival in gastrointestinal leiomyosarcomas. Implications for surgical management and staging. Ann Surg, 1992 , 215 : 68.
  • 6Chou FF, Eng HL, Sheen- Chen SM, et al. Smooth musde tumors of the gastrointestinal tract: analysis of prognostic factors. Surgery, 1996,119:171
  • 7Emory TS, Sobin LH,Lukes L, et al. Prognosis of gastrointestinal smooth-muscle(stromal) tumors:dependence on anatomic site. Am J Surg Pathol, 1999,23:82.
  • 8Evans HL. Smooth muscle tumors of the gastrointestinal tract. A study of 56 cases followed for a minimum of 10 years. Cancer,1985,56:2242.
  • 9Schmid S, Wegmann W. Gastrointestinal pacemaker cell tumor: dinicopathological, immunohistochemical, and ultrastructural study with spedal reference to c - kit receptor antibody. Virchows Arch,2000,436:234.
  • 10Franquemont DW. Differentiation and risk assessment of gastrointestinal stromal tumors. Am J Clin Pathol,1995,103:41.

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