^(90)Y电沉积的实验研究

Milking Medical ^(90)Y From ^(90)Sr Solution by Electrodeposition

研究了用电沉积方法从90Sr母液中分离医用90Y的工艺条件。以0.1 mol/L pH 2.5的(NH4)2SO4溶液为电沉积底液,以铂为阳极,铂或不锈钢为阴极,控制阴极电流密度为0.5 A/cm2,电沉积50 min后,90Y在阴极沉积率>95%。阴极上的90Y用0.1~0.5 mol/L的热硝酸洗脱后再次电沉积。二次电沉积后90Y与90Sr的分离系数>8×105,90Y洗脱收率>70%。铂丝阴极上的90Y可用200~400μL,0.1~0.5 mol/L的热硝酸洗脱,制成用于标记药物的90Y溶液;沉积有90Y的不锈钢阴极经热处理后,制成心血管放射性支架或医用敷贴器,其90Y的日浸出率分别<1%和0.1%。残液中的90Sr经放置约20 d后,可用于再次分离90Y。

The technique of separating ^90y from ^90 Sr cow by electrodeposition was studied using 0. 1 mol/L pH 2.5 （NH4）2SO4 as electrodeposition solution, platinum as anode, platinum or stainless steel as cathode, the current density of cathode 0.5 A/cm^2. After electrodeposition for 50 minutes, more than 95 % ^90y were deposited quantitatively on the cathode. Though two-step electrodepositon, the ^90y/^90 Sr separative coefficient and elution recovery of ^90y were more than 8 × 10^5 and 70% respectively. The ^90y deposited on platinum cathode was eluted by 200-400μL of 0. 1～0.5 mol/L hot HNO3, which was used to label monoclonal antibodies and peptide-receptor. The stainless steel cathode with deposited ^90y can be prepared to radioactive stent or medical patch, the daily leaching efficiency of ^90y were less than 1% and 0.1% respectively. ^90 Sr remained in the deposition solution will generate new ^90y again .