中药克癀胶囊药用原料的固态发酵生产工艺研究

Solid fermentation of bulk drug for Kehuang capsules

目的根据生产需要进行固态发酵工艺的研究。方法以发酵物中人参皂苷Rg1含量为评价发酵工艺的指标,采用L9(34)正交设计试验筛选较优的发酵工艺条件。结果最佳发酵工艺条件为起始含水量50%,相对湿度90%,搅拌速度15 r.min-1,温度33℃发酵7 d。结论工艺合理可行,质量可控。

Objective To explore the solid fermentation of bulk drug. Methods The amount of ginsenoside Rg1 content was adopted to evaluate the fermentation indexes, and the L9 （3^4 ） orthogonal design experiment was adopted to screen the superior fermentation technological contidions. Results The best fermentation technology was： initial water content 50%, fermentation temperature 33 ℃, relative humidity 90% , stirring speed at 15 rpm and fermentation for 7 days. Conclusion The technology is rational and feasible with controllable quality.