正常和炎症病变牙髓中巨噬细胞的免疫组织化学研究

Immunohistochemical study on macrophage in human pulp

应用单克隆抗体免疫组织化学方法，对正常牙髓及不同病变牙髓中巨噬细胞进行了定性、定量分析，发现正常牙髓中存在少量巨噬细胞，分布于牙髓基质中；炎症性牙髓中巨噬细胞明显增加，该细胞在可逆性牙髓炎、慢性牙髓炎、慢性牙髓炎急性发作时数量无明显差异。结果表明：巨噬细胞在牙髓病变中发挥免疫调节和吞噬消化双重作用。

human pulps were studied with the immunohistochemical method using monoclonal antibody to determine the position and the amounts of macrophage in human pulp. The results are as follows:The presence of macrophage was very limited,and they scattered in normal pulp;the numbers of macrophage increased greatly in inflammatory pulps;there was no difference in reversible pulpitis,chronic pulpitis,and the acute attack stage of chronic pulpitis.The results suggest that there are roles of macrophage of immune adjustment and unspecific phagocytosis in pulpal pathologic changes.