红细胞体积和分布宽度在妊娠合并缺铁性贫血诊断中的价值

Clinical value of mean corpuscular volume and red blood cell volume distribution width in the diagnosis of iron deficiency anemia during pregnancy

目的探讨平均红细胞体积(MCV)和红细胞分布宽度(RDW)检测在妊娠合并缺铁性贫血诊断中的价值。方法605例孕妇在常规产前检查时,同时检测外周血红蛋白浓度、MCV、RDW、及空腹血清铁浓度、总铁结合力、运铁蛋白饱和度等指标。按检测结果分为缺铁性贫血组68例、非缺铁性贫血组57例、健康对照组480例。结果缺铁性贫血与非缺铁性贫血比较,缺铁性贫血组RDW均未见上升,而MCV下降(P均<0.01);非缺铁性贫血组与对照组比较,MCV和RDW差异均无统计学意义(P均>0.05)。结论MCV降低和RDW升高为贫血的特征性改变,MCV和RDW检测有助于妊娠合并缺铁性贫血的鉴别诊断。

Objective To evaluate the value of combined measurement of mean corpuscular volume （MCV） and red blood cell volume distribution width （RDW） in the diagnosis of iron deficiency anemia during pregnancy. Methods Hemoglobin concentration （HGB）, MCV, RDW, serum iron concentration （Fe）, total iron binding capacity （TIBC） and transferring saturation percentage （TS%） were simultaneously measured in 605 pregnant women at prenatal examination. According to detective results, the 605 subjects were divided into IDA group （n=68）, other anemia group （n= 57） and healthy control group （n= 480）. Results RDW increased and MCV decreased significantly in iron deficiency anemia group compared with that of other anemia group （P〈0. 01 ）. There were no significant differences of MCV and RDW between control group and other anemia group. Conclusion Low MCV and high RDW were the characteristic changes of iron deficiency anemia during pregnancy. Combined measurement of RDW and MCV contributes to the differential diagnosis of IDA during pregnancy.