透皮促渗方法联合应用的研究进展

Advancement on combined application of percutaneous permeation methods

透皮给药系统具有传统给药方式不可比拟的优势。但由于药物的低渗透量,使其应用受到一定限制。各种物理的、化学的促渗方法,包括透皮吸收促进剂、超声导入法、离子导入法、电穿孔法等可改善皮肤透过性,增加药物的透皮速率。而且几种方法联合应用的促渗效果更加显著。本文总结了近年来各种促渗方法联合应用的研究进展。

Transdermal drug delivery system had an incomparable superiority to traditional medication systems, but its application was limited by low skin permeability. Although plenty of physical and chemical enhancement methods such as penetration enhancers, iontophoresis, sonophoresis and electroporation and so on may improve the skin permeability and permeating velocity, but combinations of several enhancement methods could enhance transdermal transport more effectively than each of them alone. This paper summarizes the progress in research on the combined application of various enhancement methods.