膀胱小细胞神经内分泌癌临床病理分析

Clinic pathology analysis of small cell carcinoma of urinary bladder

目的探讨膀胱小细胞神经内分泌癌的临床病理特征和生物学行为。方法回顾分析膀胱小细胞神经内分泌癌1例并复习有关文献予以讨论。结果患者中术前未得到明确的病理诊断,术后2周恢复良好,痊愈出院。病理检查:肿瘤细胞表达神经内分泌标记物神经原特异性烯醇酶、嗜铬粒蛋白A和突触素。结论膀胱小细胞神经内分泌癌是一种比较少见的高度恶性肿瘤,有独特的病理形态,早期即可发生转移,预后凶险,活检容易漏诊。

Objective To study the clinical histological and immunohistochemical characteristics of small cell neuroendocrine carcinoma （SCC） of the urinary bladder and biological behavior. Methods One case of bladder neuroendocrine carcinoma was analyzed retrospectively. Results Definite pathologic diagnosis in the case wasn＇t confirmed before operation. The patient recovered well two week after operation. By pathological examination the neuroendocrinic markers,such as NSE , CgA , and Syn were expressed in the tumor cell. Conclusion SCC of the urinary bladder is rare and highly malignant tumor with distinct pathological features. It is aggressive with early metastases and has a poor prognosis. It is often misdiagnosed by biopsy.