支气管哮喘气道炎症无创检测技术的应用与评价

Clinical Evaluation of Noninvasive Techniques for Inflammatory Monitoring in Asthma Patients

对支气管哮喘气道炎症进行评估和监测对于评价病情、治疗反应以及预测急性发作和预后具有重要的意义。目前相关的检测技术包括无创技术和有创技术,无创检测技术主要有气道反应性测定、诱导痰检测、呼出一氧化氮(NO)测定、呼出气冷凝物检测以及血液、尿液当中炎性介质的检测,常用的测定指标包括NO以及代谢产物、H2O2、嗜酸粒细胞计数及其颗粒蛋白、白三烯等等。在应用于临床时还需要解决标本采集的标准化问题。

It is essential to assess and monitor airway inflammation in asthmatic patients for evaluating asthma severity and therapy response, predicting acute exacerbation and outcome. Invasive and noninvasive techniques could he used , in which noninvasive techniques include airway responsiveness, induce sputum, expired NO, exhaled breath condensate, peripheral blood and urine. A variety of inflammatory indices obtained by these techniques could be assayed, mainly NO and metabolites, eosinophil counts and granular protein contents, and leukotrients. The first step in clinical practice is sampling procedure standardization.