疏肝活血方药对实验性动脉粥样硬化血清钙离子及环核苷酸浓度的影响

Effect of Soothing Liver and Promoting Blood Circulation on Pathogenic Course of Experimental Rabbit Atherosclerosis in Blood Calcium and Cyclic Nucleoside-phosphate

采用胆固醇饲喂日本大耳白家兔3个月，以造成主动脉粥样硬化病变模型，在建立动物模型的同时，给予疏肝活血复方中药，待实验结束时，取血测试，观察该中药对血钙浓度，血浆环核苷酸浓度的影响，结果显示，该中药可明显降低Ca2＋浓度，升高环磷酸腺苷（cAMP）／环磷酸鸟苷（cGMP）比值。提示疏肝活血方对动脉粥样硬化（As）的防治起到积极作用。

Atherosclerotic model of rabbit was established by feeding cholesterol for three months. At the same time,part of the animals were treated with prescription to soothe, the liver and promote blood circulation.Blood samples were taken at the end of the experiment to examine the effect on blood calcium concentration and cyclic nucleoside-phosphate content. Results showed that the prescription could significantly reduce blood calcium,and raise cAMP/cGMP ratio which suggested that the prescription could restrain the formation of atherosclerosis effectively,and also delay its development