薄荷醇与冰片的促透作用

Effect of 1-Menthol and Synthetic Borneol on Enhanced Percutaneous Penetration

研究薄荷醇和冰片对双氯灭痛的经皮透过作用，发现二者均可使双氯灭痛的透过量增加，但作用较氮酮为弱；同时发现二者的滞后时间比氮酮显著为短。结果提示，薄荷醇和冰片可望作为促透剂在某些药物的透皮给药制剂中得到应用。

Effect of 1-menthol and synthetic borneol on percutaneous penetration of diclofenac sodium was examined. It was found that both 1-menthol and synthetic borneol could increase percutaneous penetration of diclofenac sodium,but much weaker when compared with azone,and with shorter lag times (T1ag). The rusults indicated that 1-menthol and synthetic borneol could be used in transdermal delivery system of some drugs as transdermal enhancers