单疱角膜炎患者外周血白细胞介素Ⅱ活性与自然杀伤细胞活性的关系

IL 2 Activity of Peripheral Blood from Patients with Herpes Simplex Keratitis and ItsRelation with NK Cell Activity

目的了解单疱角膜炎（ＨＳＫ）患者的细胞免疫功能状态，从免疫学角度探讨ＨＳＫ的发病与复发机制。方法检测４０例正常人，２８例活动期ＨＳＫ（上皮型１３例、基质型１５例），２１例非活动期ＨＳＫ的外周血淋巴细胞白细胞介素Ⅱ（ＩＬ－２）活性及自然杀伤细胞（ＮＫ）活性水平。结果ＨＳＫ患者的ＩＬ－２及ＮＫ活性明显低于正常人，二者呈正相关关系，且基质型ＨＳＫ的变化显著。结论在ＨＳＫ的发生与发展过程中有免疫机制的参与，表现为细胞免疫功能低下。

bjectiveThe clinical significance and mechanism of HSK relapse were discussed.The cellular immune activity was detected.MethodsIL 2 activity and NK cell activity of peripheral blood lymphocytes were detected in 40 healthy adults.28 patients with active herpes simplex keratitis(HSK),in cluding 13 superficial and 15 stromal types,21 patients with inactive HSK.ResultsThe activity of IL 2 and NK cells in the patients with HSK were significantly lower than in healthy adults.There was a positive correlation between IL 2 and NK activity.ConclusionThe results suggest that cell immune activity is lower in HSK.