唾液酸、急性期蛋白对喉癌的诊断价值

Diagnostic value of sialic acid and acute phase proteins for laryngeal carcinoma

本文测定２２６例喉癌、２６例炎症，２７例良性肿瘤和５８例正常人血清唾液酸（ＳＡ）和急性期蛋白（ＡＰＰｓ）：前清蛋白、α１—抗胰蛋白酶、α１—酸性糖蛋白、触珠蛋白、转铁蛋白含量，探讨ＳＡ和ＡＰＰｓ对喉癌的诊断价值。将上述测定值经判别分析法，采用计算机辅助进行判别诊断。结果发现：喉癌治疗前和正常人判别诊断与临床、病理诊断之符合率为８８．８％；新病例（前瞻性判别）符合率为８６％。喉癌治疗无复发和复发之判别符合率为８９．５％；新病例判别其符合率为８６．１％。炎症、良性肿瘤对判别无明显干扰。结果表明：ＳＡ与ＡＰＰｓ喉癌诊断有临床应用价值。

To evaluate the diagnostic value of sialic acid (SA)and acute phase proteins(APPs)for laryugeal carcinoma(LC),the SA and APPS(Prealbumin,α 1-Antitrypsin,α 1-Acid glycoprotein,Haptoglobin.Transferrin)were determined,and the discriminant functions,by which the discriminant diagnosis was made established.The discriminant function(Ⅰ)for discriminant diagnosis of LC was derived from the data of 58 patients with LC and 58 healthy subjects,another one (Ⅱ)for follow-up after treatment from 19 patients had recurrence or metastasis and 20 tumour-free patients after cure.The discriminnt diagnosis was made with (Ⅰ)for 103 patients unknown diagnosis at the time of presentation.Comparing with histological diagnosis,the precision of discriminant diagnosis was86%, Following-up 79 patients with LC after treatment,the precision of discriminant diagnosis with (Ⅱ) to detect recurrence or metastasis was 86 1%。 In conclusion,determination of SA and APPs can used for diagnostic and prrognostic purpose.