活动期溃疡性结肠炎血液流变学及复方丹参治疗的临床研究

The Study on Hemorrheological Changes of Patients with Active Ulcerative Colitis and the Treatment of This Disease with Compound Red Sage Root

为观察研究溃疡性结肠炎（UC）血液流变学的变化及采用活血化瘀法治疗的效果，对67例活动期UC患者进行血液流变学检测，包括全血黏度低切值、全血黏度高切值、血浆黏度、全血还原黏度、红细胞体积比、红细胞聚集指数、血沉及血沉方程K值，并与60例健康体检者比较。将67例活动期UC患者分为治疗组34例和对照组33例，对照组采用常规治疗，治疗组加用丹参治疗，观察1个月后的有效率及3个月、6个月的复发率。结果显示，活动期UC患者血液流变学指标除红细胞刚性指数外均显著高于健康体检者；治疗组治愈率44．1％，有效率50．0％，总有效率94．1％，3个月复发率为0，6个月复发率11．8％；对照组治愈率12．1％，有效率51．5％，总有效率63．6％，3个月复发率12．1％，6个月复发率42．4％，治疗组治愈率、总有效率显著高于对照组（P〈0．01），3个月和6个月复发率明显低于对照组（P〈0．01）。结果表明，UC患者存在血液高凝状态，在基础治疗的同时加用复方丹参治疗UC能提高疗效，降低复发率。

The aim of this study wasto investigate the hemorrheological changes of patients with ulcerative colitis（UC） and outcome of ＂promoting blood flow and resolving blood stasis＂ therapy for this disease. The 67 patients with active UC were subjected to items detection including high shear value and low shear value of whole blood viscosity, plasma viscosity, reduction viscosity of whole blood,hematocrit, erythrocyte aggregation index, erythrocyte sedimentation rate, as well K value of erythrocyte sedimentation rate equation. The obtained data were compared with those of 60 healthy subjects. The 67 patients were divided into treatment group（ n = 34） and controlled group（ n = 33）. Controlled group received routine therapy, treatment group again added compound red sage root therapy. Then one month after treatment, as well 3,6 monthes after treatment the effective rate, as well recurrence rates were observed respectivelly. As results, except for erythrocyte rigidity index, other hemorrheological indexes of active UC patients were significantly higher than those of healthy subjects. The curative rate,effective rates and total effective rate of treatment group were 44.1 %,50.0% and 94.1 % and the recurrence rates of 3,6 monthes after treatmnet were 0,11.8% ,respectively. These data in controlled group were 12.1% ,51.5% ,63.6% ,as well 12.1% ,42.4% respectively. Between both groups there was significant difference（ P 〈%0.01）. It is suggested that in UC patients there is high aggregation, routine therapy combined with red sage root could enhance therapeutic effects and reduce recurrence rate.