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Dynamics of network motifs in genetic regulatory networks

Dynamics of network motifs in genetic regulatory networks
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摘要 Network motifs hold a very important status in genetic regulatory networks. This paper aims to analyse the dynamical property of the network motifs in genetic regulatory networks. The main result we obtained is that the dynamical property of a single motif is very simple with only an asymptotically stable equilibrium point, but the combination of several motifs can make more complicated dynamical properties emerge such as limit cycles. The above-mentioned result shows that network motif is a stable substructure in genetic regulatory networks while their combinations make the genetic regulatory network more complicated. Network motifs hold a very important status in genetic regulatory networks. This paper aims to analyse the dynamical property of the network motifs in genetic regulatory networks. The main result we obtained is that the dynamical property of a single motif is very simple with only an asymptotically stable equilibrium point, but the combination of several motifs can make more complicated dynamical properties emerge such as limit cycles. The above-mentioned result shows that network motif is a stable substructure in genetic regulatory networks while their combinations make the genetic regulatory network more complicated.
出处 《Chinese Physics B》 SCIE EI CAS CSCD 2007年第9期2587-2594,共8页 中国物理B(英文版)
基金 Project supported by the National Natural Science Foundation of China (Grant No 10672093) and Innovation Foundation of , Shanghai University for Postgraduates, China.
关键词 genetic regulatory network MOTIF feedback loop genetic regulatory network, motif, feedback loop
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